Immunological Tolerance Induced in Animals Previously Sensitized to Simple Chemical Compounds

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Science  15 May 1964:
Vol. 144, Issue 3620, pp. 853-854
DOI: 10.1126/science.144.3620.853


Adult guinea pigs develop a delayed hypersensitivity to intradermally injected neoarsphenamine. If the animals are treated intravenously with high doses of this compound before sensitization, a specific and permanent immunological tolerance develops. Permanent tolerance is also obtained in previously sensitized animals when an intravenous injection of neoarsphenamine isfollowed 6 hours later by an intradermal one. When, however, the interval between the two injections is extended to 7 or 14 days, no tolerance is observed.