Pluripotent Stem Cell Function of the Mouse Marrow "Lymphocyte"

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Science  15 May 1964:
Vol. 144, Issue 3620, pp. 866-868
DOI: 10.1126/science.144.3620.866


Bone marrow from normal and polycythemic mice was filtered through glasswool columns to remove cells other than "lymphocytes." For a given number of nucleated cells, filtered marrow was more efficient than the original marrow in repopulating the spleen of an isogenic recipient previously exposed to lethal irradiation. The proliferative capacity of both the filtered and unfiltered marrow suspensions appeared to be a constant function of the number of small and medium "lymphocytes" present and not of any other cell type.