Serologic Typing of Human Lymphocytes with Immune Serum Obtained after Homografting

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Science  15 May 1964:
Vol. 144, Issue 3620, pp. 868-870
DOI: 10.1126/science.144.3620.868


Serums obtained from paired humans following reciprocal fourthset skin homografts, or from a prolonged series of reciprocal intradermalinjections of leukocytes, displayed potent cytotoxic activity againstlymphocytes of certain individuals and no activity against lymphocytes of other persons. Study of one family suggested that lymphocyte reactivity may be transmitted according to simple Mendelian genetics. Itis probable that this reactivity reflects and can be used to identifyspecific histocompatibility antigens in man.