Serotonin Deficiency in Infancy as One Cause of a Mental Defect in Phenylketonuria

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Science  15 May 1964:
Vol. 144, Issue 3620, pp. 883-884
DOI: 10.1126/science.144.3620.883


Serotonin deficiency induced in newborn mice and maintained to adulthoodresulted in reduced ability to learn a maze. The serotonin deficiency was produced by overloading with phenylalanine plus tyrosine (to cause phenylketonuria), by feeding of reserpine, and by feeding of chlorpro mazine from birth to maturity.