Psychological Changes Associated with Induced Hyperammonemia

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Science  15 May 1964:
Vol. 144, Issue 3620, pp. 886-888
DOI: 10.1126/science.144.3620.886


Normal volunteers infused with ammonium acetate for 3 hours developed a characteristic behavior pattern resembling that of prehepatic coma. They demonstrated certain specific defects in motor performance and recognition aswell as significant lowering of critical flicker fusion. These findings arecorrelated with the concentration of ammonia in arterial blood.