Reports

Synthesis of RNA in vitro Stimulated in Dipteran Salivary Glands by 1,1,3-Tricyano-2-Amino-1-Propene

Science  22 May 1964:
Vol. 144, Issue 3621, pp. 1011-1012
DOI: 10.1126/science.144.3621.1011

Abstract

1,1,3-Tricyano-2-amino-1-propene stimulates by more than one order of magnitude the incorporation in vitro of uridine into the RNA of dipteran salivary glands. The inhibition by actinomycin D is blocked. Higher doses cause a complete inhibition from which a proportion of the glands recover rapidly upon withdrawal of the substance.

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