Haptoglobin Binding Capacity of Certain Abnormal Hemoglobins

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Science  22 May 1964:
Vol. 144, Issue 3621, pp. 1014-1015
DOI: 10.1126/science.144.3621.1014


Hemoglobins H and Bart's failed to bind human haptoglobin. The binding of hemoglobins A1, F, I, and Lepore was comparable to that of hemoglobin A. These findings suggest that configurational differences or the absence of alpha chain dimers was responsible for the lack of binding of hemoglobins H and Bart's.