Interferon Production in Chickens Injected with Brucella abortus

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Science  22 May 1964:
Vol. 144, Issue 3621, pp. 1022-1023
DOI: 10.1126/science.144.3621.1022


Intravenous injection of large numbers of live, virulent Brucella abortus in chickens resulted in the appearance in the serum of a viral inhibitor indistinguishable from interferon. Inhibitor was detected as early as 3 hours after inoculation of brucellae and reached a peak between 6 and 12 hours.