Citrate Cleavage Enzyme in Livers of Obese and Nonobese Mice

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Science  22 May 1964:
Vol. 144, Issue 3621, pp. 1027-1028
DOI: 10.1126/science.144.3621.1027


The specific activity of the citrate cleavage enzyme is 3.3 times greater in livers of obese mice than in livers of their nonobese litter mates. The difference persists during starvation. The specific activity of the acetate activating enzyme is approximately the same in the livers of both types of animals. It is proposed that a high activity of citrate cleavage enzyme is one of the factors responsible for obesity.