Affinity and Phosphorylation Constants for the Inhibition of Esterases by Organophosphates

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Science  22 May 1964:
Vol. 144, Issue 3621, pp. 992-993
DOI: 10.1126/science.144.3621.992


Equations based on the assumption of a reversible first step in the reaction between organophosphate inhibitors and esterases are proposed for the bimolecular rate constant which now includes an affinity constant and a phosphorylation constant. The treatment applies when the inhibition reaction follows first-order kinetics.