Eserine and Amphetamine: Interactive Effects on Sleeping Time in Mice

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Science  05 Jun 1964:
Vol. 144, Issue 3623, pp. 1221-1222
DOI: 10.1126/science.144.3623.1221


The sleeping time of mice given pentobarbital was found to be significantly shortened by the injection of eserine or amphetamine. When both eserine and amphetamine were given with pentobarbital the sleeping time, though much shortened, was significantly longer than with the addition of amphetamine alone. Though possessing an analeptic effect of its own, eserine appears to antagonize the analeptic effect of amphetamine.