Procaine Action: Antagonism by Adenosine Triphosphate and Other Nucleotides

See allHide authors and affiliations

Science  05 Jun 1964:
Vol. 144, Issue 3623, pp. 1222-1223
DOI: 10.1126/science.144.3623.1222


Appropriate concentrations of adenosine tri-, di-, and monophosphate antagonize the depressant action of procaine on isolated nerve. Some calcium ion is required in the external solution in order for these nucleotides to produce their maximum effects. When applied either to normal or sodium deficient nerves, the nucleotides do not increase action-potential amplitude.