DNA Contents of Chromosome Ph1 and Chromosome 21 in Human Chronic Granulocytic Leukemia

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Science  05 Jun 1964:
Vol. 144, Issue 3623, pp. 1229-1232
DOI: 10.1126/science.144.3623.1229


The Philadelphia chromosome, characteristic of chronic granulocytic leukemia, contained 61±1 percent as much DNA as a number 21 (or 22) chromosome from which it is believed to be derived. The remaining 39 percent represents 0.5 percent of a diploid chromosome complement, approximately 2 x 107 nucleotide pairs; the method used was not sensitive enough to detect whether it had been translocated to other chromosomes.