Rous Sarcoma in Chinese Hamsters

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Science  05 Jun 1964:
Vol. 144, Issue 3623, pp. 1232-1233
DOI: 10.1126/science.144.3623.1232


A variant of the Rous sarcoma virus induced tumors in newborn Chinese hamsters within 2 to8 weeks. The tumors grew progressively and sometimes metastasized. They were successfully transplanted in series in Syrian hamsters. The chromosomes of the tumors in the Chinese hamstersas well as of those transplanted into the Syrian hamsters were Chinese hamster chromosomes. Virus was demonstrated in the Chinese hamster tumors by injecting material from the tumors into chickens, where Rous sarcomas subsequently appeared.