Hemoglobin Polymorphism: Its Relation to Sickling of Erythrocytes in White-Tailed Deer

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Science  05 Jun 1964:
Vol. 144, Issue 3623, pp. 1237-1239
DOI: 10.1126/science.144.3623.1237


Hemoglobins with different electrophoretic mobilities are associated with bizarre shapes seen during ordinary light microscopy of erythrocytes from the white-tailed deer, Odocoileus virginianus; nonsickling is contingent upon a specific hemoglobin. Sickling in vitro, which isproduced to a maximum degree in the presence of oxygen and elevated pH, is not associated with hematological abnormalities or disease despite marked differences in physical characteristics of sickled and nonsickled cells.

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