Hyperbaric Exposure of Mice to Pressures of 60 to 90 Atmospheres

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Science  05 Jun 1964:
Vol. 144, Issue 3623, pp. 1241-1242
DOI: 10.1126/science.144.3623.1241


Albino mice breathing helium-oxygen mixtures remained in good condition for periods of 1 to 13 hours at pressure-equivalent depths of 396 to 914 meters of sea water. They were successfully decompressed to normal atmospheric pressure in less than 5 hours. There were no immediate or delayed adverse effects that could be attributed to the hyperbaric helium-oxygen environment. An occasional death was attributable to hypoxia or the decompression procedure.