RNA Synthesis in Rat Seminal Vesicles: Stimulation by Testosterone

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Science  12 Jun 1964:
Vol. 144, Issue 3624, pp. 1346-1347
DOI: 10.1126/science.144.3624.1346


Within 70 minutes after the administration of testosterone to rats castrated 12 to 15 hours previously, the rate of synthesis of RNA in the seminal vesicle is increased by 50 percent and continues to rise until approximately 50 minutes after injection when a two- to threefold increase was attained. No further increase was detected for as long as 240 minutes after hormone administration. The base composition of the pulse-labeled RNA was intermediate between that of the total seminal vesicle RNA and DNA-like RNA. No change in this composition was detected at any interval after injection.