5-Iodo-2'-Deoxyuridine: Relation of Structure to Its Antiviral Activity

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Science  12 Jun 1964:
Vol. 144, Issue 3624, pp. 1348-1350
DOI: 10.1126/science.144.3624.1348


The crystal and molecular structure of 5-iodo-2'-deoxyuridine has been determined by x-ray diflraction methods. The most interesting feature of the structure is an unusually short intermolecular distance between the iodine and oxygen of a carbonyl group; this type of bonding may be the molecular basis for the antiviral activity. a different crystal structure.