Temperature Dependence of Anesthesia in Goldfish

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Science  19 Jun 1964:
Vol. 144, Issue 3625, pp. 1460-1462
DOI: 10.1126/science.144.3625.1460


The anesthetizing concentrations in water of diethyl ether, chloroform, halothane (CF3CClBrH), and methaxyflurane (CHCl2CF2OCH3) have been determined for temperature-acclimated goldfish (Carassius auratus) at 5° to 30°C. At 20°C, the concentrations that anesthetize 50 percent of the fish are 2160, 167, 76.4, and 57.0 mg/ liter, respectively; the corresponding partial pressures are 13.0, 3.36, 4.12, and 0.67 mm-Hg. The anesthetizing partial pressures increase with body temperature, with enthalpies of 8.6, 13.2, 12.5, and 12.3 kcal/ mole, respectively.