Thalidomide: Effects on Ehrlich Ascites Tumor Cells in vitro

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Science  26 Jun 1964:
Vol. 144, Issue 3626, pp. 1583
DOI: 10.1126/science.144.3626.1583


Thalidomide did not inhibit dehydrogenase activity or growth of Ehrlich ascites tumor cells in agar. When mixed with Ehrlich ascites tumor cells in vitro, thalidomide increased the mitotic activity. The effect of the thalidomide was not altered by the addition of nicotinic or folic acid, or by vitamin B1 or B6. Oxygen uptake by the tumor cells was not affected by thalidomide.