Diphtheria Antitoxin: Antigen-Combining and Toxin-Neutralizing Properties of Papain Fragments

Science  26 Jun 1964:
Vol. 144, Issue 3626, pp. 1585-1586
DOI: 10.1126/science.144.3626.1585


Papain-digested rabbit antibodies to diphtheria toxoid were separated into three fragments. Fragments I and II combined with toxoid in vitro and neutralized toxin. The ratios of these activities were not the same for fragments I and II, indicating that antitoxic and accessory antibody may be distributed unequally between two classes of antibody.