Polypeptide Chains of Human Gamma-Globulin: Cellular Localization by Fluorescent Antibody

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Science  26 Jun 1964:
Vol. 144, Issue 3626, pp. 1590-1591
DOI: 10.1126/science.144.3626.1590


Fluorescent antibody to antigenically distinct portions of 7S gammaglobulin was used to study the occurrence of H-chains and L-chains of types I and II within single cells. Individual lymphoid cells contained both H-and L-chains, but individual cells did not contain both antigenic types of L-chains.