Pyruvate Metabolism and Control: Factors Affecting Pyruvic Carboxylase Activity

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Science  03 Jul 1964:
Vol. 145, Issue 3627, pp. 58-60
DOI: 10.1126/science.145.3627.58


Pyruvic carboxylase activated by acetyl coenzyme A is highly active in the mitochondria of rodent liver, and its activity is increased in fasting and alloxan diabetes. In conjunction with acyl carboxylase activated by di- and tricarboxylic acid, it forms a reciprocating control network. Analog models of similar networks tend to correct for perturbations, stabilizing the overall system.