Distributive Pairing and Aneuploidy in Man

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Science  03 Jul 1964:
Vol. 145, Issue 3627, pp. 66-67
DOI: 10.1126/science.145.3627.66


The extrapolation of the "distributive-pairing hypothesis" of meiosis in Drosophila melanogaster females to human gametogenesis is proposed to account for the co-occurrence of rare karyotype abnormalities in human families. A description of the hypothesis is presented with its application to some established cases in the cytogenetic literature.