Gamma Globulin: Unmasking of Hidden Antigenic Sites on Light Chains

See allHide authors and affiliations

Science  10 Jul 1964:
Vol. 145, Issue 3628, pp. 167-168
DOI: 10.1126/science.145.3628.167


Normal light (L) chains cleaved from normal pooled human gamma globulin contain immunologic determinants not overtly present in the native unreduced molecule. These hidden determinants are shared with Bence Jones proteins. Similarly, one of two Bence Jones proteins contained immunologic determinants which were not overtly present on the autologous serum myeloma protein.