Uracil: Failure To Restore DNA Synthesis While Relieving 5-Fluorouracil-Induced Inhibition

Science  17 Jul 1964:
Vol. 145, Issue 3629, pp. 276-277
DOI: 10.1126/science.145.3629.276


Growth inhibition of Bacillus cereus by 5-fluorouracil is abolished by the addition of uracil without the inhibition of DNA synthesis being relieved. The growth rate, protein, and RNA content of cells grown in the presence of 5-fluorouracil and uracil are unaffected until the cells contain only about 25 percent of their normal DNA content.