Inhibition of 19S Antibody Synthesis by 7S Antibody

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Science  24 Jul 1964:
Vol. 145, Issue 3630, pp. 395-397
DOI: 10.1126/science.145.3630.395


A brief course of treatment with 6-mercaptopurine prevented conversion of 19S to 7S antibodies during the immune response of rabbits to bovine gamma globulin. Specific reactive homologous 7S antibodies given intravenously to animals with such incompletely developed humoral reactions led to an abrupt fall in 19S antibodies. After a lag period the synthesis of 7S antibodies was apparently normal. These results suggest that the concentration of 7S antibodies controls the synthesis of 19S antibodies.