Alkylation of Synthetic Polynucleotides

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Science  24 Jul 1964:
Vol. 145, Issue 3630, pp. 397-399
DOI: 10.1126/science.145.3630.397


The synthetic polynucleotides may be used as models for the effects of alkylating agents on nucleic acid. Alkylation of polyadenylic acid with methyl methanesulfonate yields a polymer methylated in the one-position of adenine. This alteration in structure produces marked changes in physical properties and decreases the capacity to code for polylysine synthesis.