Reports

Alkylation of Synthetic Polynucleotides

+ See all authors and affiliations

Science  24 Jul 1964:
Vol. 145, Issue 3630, pp. 397-399
DOI: 10.1126/science.145.3630.397

Abstract

The synthetic polynucleotides may be used as models for the effects of alkylating agents on nucleic acid. Alkylation of polyadenylic acid with methyl methanesulfonate yields a polymer methylated in the one-position of adenine. This alteration in structure produces marked changes in physical properties and decreases the capacity to code for polylysine synthesis.

Related Content