Structural Differences between Two Types of "Heavy Chain" Disease Proteins and Myeloma Globulins of Corresponding Types

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Science  31 Jul 1964:
Vol. 145, Issue 3631, pp. 499-500
DOI: 10.1126/science.145.3631.499


Structural differences between two antigenic types (designated C and Z) of γ-globulins, both of low molecular weight, produced in " Heavy chain" disease are revealed by their relative susceptibilities to enzymatic degradation by papain and the nature of the cleavage products. Corresponding structural differences exist between the respective type C and type Z myeloma γ2-globulins. These structural differences are tentatively assigned to the H-chains, and more specifically to the portion of the H-chain contained in the fast-moving (F) fragment of papain-treated γ2-globulins.