Polydactylism in the Offspring of Mice Injected with 5-Bromodeoxyuridine

See allHide authors and affiliations

Science  31 Jul 1964:
Vol. 145, Issue 3631, pp. 501-503
DOI: 10.1126/science.145.3631.501


The intraperitoneal injection of multiple doses of 5-bromodeoxyuridine (BUDR) into pregnant mice produced abnormalities limited to the hind limbs of the offspring. This effect is probably a result of a metabolic lesion. When injected into newborn mice, BUDR did not increase the incidence of tumors.