Therapeutic Antiviral Action of 5-Trifluoromethyl-2'-deoxyuridine in Herpes Simplex Keratitis

See allHide authors and affiliations

Science  07 Aug 1964:
Vol. 145, Issue 3632, pp. 585-586
DOI: 10.1126/science.145.3632.585


5-Trifluoromethyl-2'-deoxyuridine (F3TDR) has potent therapeutic antiviral activity in herpes simplex infection of the rabbit cornea with strains of herpes virus both sensitive and resistant to 5-iodo-2'-deoxyuridine, and in corneal infection with vaccinia. 5-Trifluoromethyl uracil is not therapeutically active in herpetic keratitis.