Human Erythrocyte Lactate Dehydrogenase: Four Genetically Determined Variants

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Science  07 Aug 1964:
Vol. 145, Issue 3632, pp. 595-597
DOI: 10.1126/science.145.3632.595


Four variants of human erythrocyte lactate dehydrogenase (LDH) are described. One of these is similar to the one previously described by Boyer and is interpreted as a variant of LDH-B. The other three are thought to represent variants of LDH-A. Studies of families indicate that LDH-A and LDH-B are under separate genetic control and are inherited as autosomal co-dominants. Evidence is presented that the LDH-A locus is not closely linked to the loci for the ABH and Duffy blood group systems.