Oxidation of Extramitochondrial Diphosphopyridine Nucleotide by Various Tissues of the Mouse

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Science  07 Aug 1964:
Vol. 145, Issue 3632, pp. 606-607
DOI: 10.1126/science.145.3632.606


Exogenous reduced diphosphopyridine nucleotide was not oxidized by mitochondria but by cytoplasmic hydrogen-accepting systems catalyzed by lactic, α-glycerophosphate, and malic dehydrogenases. The three enzymes were found in all tissues of the mouse; the amount of activity of each enzyme differed in the various tissues, however. It is suggested that each tissue has a unique pattern for oxidation of extramitochondrial diphosphopyridine nucleotide.