Atrophy of Skeletal Muscle in Chick Embryos Treated with Botulinum Toxin

See allHide authors and affiliations

Science  14 Aug 1964:
Vol. 145, Issue 3633, pp. 719-721
DOI: 10.1126/science.145.3633.719


Botulinum toxin was given in large intravenous doses to 7- and 12- day chick embryos. Atrophy of skeletal muscle resulted without significant atrophy of other organs. The histological appearance of muscle was consistent with denervation. The results suggest that neural acetylcholine release may play a significant role in "trophic transmission" from nerve to muscle.