Protein as the Mitochondrial Site for Action of Uncoupling Phenols

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Science  21 Aug 1964:
Vol. 145, Issue 3634, pp. 824-826
DOI: 10.1126/science.145.3634.824


Phenolic reagents which uncouple oxidative phosphorylation are bound to the protein moiety of mitochondria. This interaction may induce configurational changes in the enzymes of oxidative phosphorylation, and these changes could be responsible for the uncoupling phenomenon