Uric Acid Transport System: Apparent Absence in Erythrocytes of the Dalmatian Coach Hound

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Science  21 Aug 1964:
Vol. 145, Issue 3634, pp. 826-827
DOI: 10.1126/science.145.3634.826


The Dalmatian coach hound appears to lack a mediated transport system for uric acid, which can be demonstrated in the erythrocytes of other dogs by hypoxanthine inhibition of uric acid uptake. This transport deficiency may be a manifestation of a genetic defect which has different metabolic consequences in the liver, in the kidney, and in other tissues, depending on the direction of their differentiation