Release of Metaraminol (Aramine) from the Heart by Sympathetic Nerve Stimulation

See allHide authors and affiliations

Science  21 Aug 1964:
Vol. 145, Issue 3634, pp. 828-829
DOI: 10.1126/science.145.3634.828


Cats were injected intravenously with metaraminol, an amine which depletes norepinephrine from the sympathetic nerve endings; their hearts were then perfused in vitro. Stimulation of the sympathetic nerve supply released metaraminol from the hearts, demonstrating that a synthetic compound can replace norepinephrine and serve as a transmitter at adrenergic nerve endings