Vitamin K Induced Prothrombin Formation: Antagonism by Actinomycin D

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Science  28 Aug 1964:
Vol. 145, Issue 3635, pp. 926-928
DOI: 10.1126/science.145.3635.926


Actinomycin D inhibits vitamin K induced formation of prothrombin in chicks deficient in vitamin K. The administration of actinomycin in doses which inhibit prothrombin formation also inhibits synthesis in the liver of RNA from adenosine triphosphate as detected with adenine-8-C14. The results are consistent with a genetic action of vitamin K in inducing RNA formation for the synthesis of clotting proteins