Thymectomy: Effect on Secondary Disease in Radiation Chimeras

Science  28 Aug 1964:
Vol. 145, Issue 3635, pp. 935-936
DOI: 10.1126/science.145.3635.935


The pattern of secondary mortality in mice after irradiation and hemopoietic cell transplantation was changed by thymectomy of the recipients 3 weeks before irradiation. In isologous and parent-to-F1 chimeras excess mortality was occurring later than the usual period of secondary disease. In thymectomized heterologous chimeras secondary mortality was decreased and delayed