Redifferentiation of Connective Tissue Cells in Serial Culture

See allHide authors and affiliations

Science  04 Sep 1964:
Vol. 145, Issue 3636, pp. 1053-1054
DOI: 10.1126/science.145.3636.1053


When cell cultures are initiated from aortic connective tissue of rats and maintained as monolayers on glass, the differentiated property of collagen production disappears. However, these same cells, when placed in diffusion chambers in the peritoneal cavities of other rats, produce collagen, as indicated both morphologically and by the accumulation of hydroxy-proline within the chambers.