Adenovirus-like Particles from Cancers Induced by Adenovirus-12 but Free of Infectious Virus

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Science  11 Sep 1964:
Vol. 145, Issue 3637, pp. 1190-1192
DOI: 10.1126/science.145.3637.1190


Particles resembling adenovirus were recovered from tumors induced by adenovirus-12. The particles were similar to incomplete adenovirus in size, subunit morphology, and density. The presence of such incomplete viral units helps to explain why attempts to isolate infectious virus from adenovirus-induced tumors have failed despite the serological evidence that viral elements are present.