Inhibition of Specific Binding of Antibody to the Rh0(D) Factor of Red Cells in Antibody Excess

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Science  11 Sep 1964:
Vol. 145, Issue 3637, pp. 1197-1199
DOI: 10.1126/science.145.3637.1197


The uptake by red cells of I131-labeled nonagglutinating antibody to the Rh0(D) factor was dependent on the proportion of cells to antibody during sensitization. Inhibition of antibody binding by red cells in the region of antibody excess occurred with Rh0(D) positive red cells that were both papain modified and untreated; the inhibition was independent of the Rh phenotype.