Reports

Skin Tumorigenesis by 7,12-Dimethylbenz(a)anthracene: Inhibition by Actinomycin D

Science  18 Sep 1964:
Vol. 145, Issue 3638, pp. 1321-1322
DOI: 10.1126/science.145.3638.1321

Abstract

Topical application of actinomycin D during a short period of time immediately before and after a single application of 7, 12-dimethyl-benz (a)anthracene markedly inhibits subsequent tumor formation. The results indicate that the initial events of carcinogenesis are dependent on DNA-dependent RNA synthesis.

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