Homograft Target Cells: Specific Destruction in vitro by Contact Interaction with Immune Macrophages

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Science  25 Sep 1964:
Vol. 145, Issue 3639, pp. 1427-1429
DOI: 10.1126/science.145.3639.1427


Specific adherence and mutual immunologic destruction occurred after contact in vitro of immune peritoneal macrophages from C57BI/6K mice with homograft target cells from A/Jax mice. Cell destruction apparently resulted from a nonphagocytic mechanism involving cell contact rather than humoral antibody. Cell destruction was determined by a plaque technique with either immunecells or target cells as monolayers.