Mycotoxins: Aflatoxin Isolated from Penicillium puberulum

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Science  25 Sep 1964:
Vol. 145, Issue 3639, pp. 1439
DOI: 10.1126/science.145.3639.1439


Penicillium puberulum Bainer was found growing on a sample of moldy peanuts. It also grows on shredded wheat, potatoes, and laboratory culture media such as wort, potato dextrose, and Sabouraud agars, and synthesizes aflatoxin on these substrates. Thin-layer chromatograms of the chloroform-soluble toxin produced by the mold when grown on shredded wheat show fluorescent bands with RF values identical with those of the fractions B1, B2, G1, and G2 of the toxin produced by Aspergillus flavus. This extract produces typical bile duct proliferation type of liver damage in 2-to 3-day-old Peking white ducklings.