Reduction of Cardiac Stores of Norepinephrine in Experimental Heart Failure

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Science  25 Sep 1964:
Vol. 145, Issue 3639, pp. 1439-1441
DOI: 10.1126/science.145.3639.1439-a


Constriction of the ascending aorta in the guinea pig resulted in ventricular hypertrophy and congestive heart failure. In animals with heart failure which were killed 5 to 40 days after constriction, the norepinephrine stores in both ventricles were strikingly reduced; the extent of reduction was related to the severity of the constriction.