Blood Groups of Chimpanzees: Demonstrated with Isoimmune Serums

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Science  25 Sep 1964:
Vol. 145, Issue 3639, pp. 1441-1443
DOI: 10.1126/science.145.3639.1441


Of five chimpanzees injected with blood of other chimpanzees in Freund's adjuvant, three produced antiserums for simian blood factors designated Ac, Bc, and Cc, respectively. Factors Ac and Bc determine four blood groups which were distributed among 60 chimpanzees in conformity with the triple-allele hypothesis. Factor Cc appears to belong to an independent blood group system. All three simian blood factors are distributed independently of sex. An antithetical relation exists between the simian blood factor Ac and blood factor Nv, the latter being a blood factor shared by all human N cells. Since the simian blood factors Ac and Bc are also related, the three blood factors Ac, Bc, and Nv must belong to one and the same blood group system, which is named the V-A-B blood group system of chimpanzees. The V-A-B blood group system of chimpanzees appears to be the counterpart of the M-N-S blood group system of man.