Poliovirus Type 1: Neutralization by Papain-Digested Antibodies

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Science  25 Sep 1964:
Vol. 145, Issue 3639, pp. 1447-1448
DOI: 10.1126/science.145.3639.1447


Papain-digested rabbit antibody (Porter's fractions I and II) can neutralize poliovirus. Neutralizing capacity after digestion ranged from 35 to 45 percent of that of the undigested antibody. No definite dissociation of the antibody fragments from the virus was observed after the reaction mixture had been diluted in a neutral medium.