Subclasses of Human γ2-Globulin Based on Differences in the Heavy Polypeptide Chains

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Science  16 Oct 1964:
Vol. 146, Issue 3642, pp. 400-401
DOI: 10.1126/science.146.3642.400


Three subclasses of human γ2-globulin (IgG) molecules were detected in normal human serum with antiserums prepared in monkeys. These subclasses, designated γ2a-, γ2b-, and γ2c-globulins, have antibody activity. The distinguishing antigenic characteristics of each subclass were associated with the heavy polypeptide chains and the F (fast) fragments resulting from treatment of γ2-globulins with papain.