Valence and Affinity of Equine Nonprecipitating Antibody to a Haptenic Group

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Science  16 Oct 1964:
Vol. 146, Issue 3642, pp. 401-403
DOI: 10.1126/science.146.3642.401


A nonprecipitable antibody to a haptenic group has been purified from equine serum. It is a 7S β2δ immunoglobulin with high affinity for the specific hapten and two binding sites per antibody molecule. These results rule out univalence and low affinity as explanations of the nonprecipitability of this antibody.